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Effect of Lycopene on Pharmacokinetic and Pharmacodynamics of Gliclazide in Diabetic Animal Models- juniper Publishers

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Juniper Publishers- Journal of Complementary Medicine Abstract Background: Diabetes mellitus is one of the metabolic disorders associated with high blood sugar levels. Utilization of natural drugs among patients under diabetes mellitus pharmacotherapy is across the board. Objective: To examine the pk-pd(pharmacodynamic-pharmacokinetic) interactions of lycopene and gliclazide in animal models and to understand the safety & effectiveness. Methods: Single and multiple dose interaction studies were carried out in normal rats, diabetes induced rats and rabbits to evaluate the effect of lycopene on the gliclazide activity. Blood samples from the study animals were used for the estimation insulin and glucose levels by using radioimmunoassay method and chemistry analyzer (automated) respectively. Homeostasis model assessment used for determination of β-cell function. Additionally, sophisticated HP-LC technique used for analysis of diabetic rabbits serum sample...
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Parental and Physician Perceptions of Medical Marijuana in the Pediatric Setting-Juniper Publishers

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Juniper Publishers Objective:  The past decades have seen several political and sociological debates regarding the legalization of medical marijuana as studies discover novel treatment benefits. In the pediatric setting, these discussions involve both parents and physicians. This study sought to identify factors that may influence the parents’ and physicians’ perceptions on medical marijuana use for children; and to determine any stigmas and concerns with its use.  Methods:  A prospective survey using a 5-point Likert scale was administered using convenience sampling of guardians with children receiving care in the pediatric emergency department, physicians working in the pediatric hospital, and providers attending the 2016 Pediatric Academic Societies Conference.  Results:  319 parents and 287 physicians participated in this study. The majority of parents were female (69.3%), white (44.2%) and 35-44 years (34.2%). The majority of physicians were female (5...
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Stress Reducing Effect of a New Appliance on Dental Implant Patients-Juniper Publishers

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Juniper Publishers Aim:  FM5 SENSORY system provides a new therapy modality which reveals synergistic effects on the level of stress. This innovative system combines music, aromatherapy and LED system by its own software program, and consist of a helmet and a main machine. By using this system, the aim of this study is to evaluate the levels of stress of the patients who would undergo dental implant surgery.  Methods:  This study included 66 of patients with no systemic disease (33 females, 33 males; mean age: 37.4±1.5 years). Evaluation of the stress levels of patients were performed by measuring the concentration of urinary cortisol. The treatment with helmet and the program of main machine were applied to all patients for 30 minutes. Before and after the treatment, twenty-four hours urine were collected from each participant. For the analyzes of cortisol levels, Urine BETA Cross Laps® (CTX-I) ELISA kit was utilized and they were presented as pg/ml. Obtained da...
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