Different Drugs in Modulating Gut Microbiome of Colitis Mice-Juniper Publishers
Juniper Publishers- Journal of complementary medicine Abstract Background: The gut microbiome plays a key role in Inflammatory Bowel Disease (IBD), which has spurred the development of novel therapeutics aimed at restoring microbial community structure. Saccharomyces boulardii is a new probiotic that has not been commonly used to treatment IBD. Although the traditional Chinese herbal medicine Sijunzi Tang (SJZT) decoction has been widely used to alleviate the symptoms of ulcerative colitis (UC), its underlying mechanism remains unknown. Methods: The efficacy of four drugs named S. boulardii , SJZT, Dangshen ( Codonopsis pilosula ) polysaccharide or S. boulardii in combination with Dangshen polysaccharide were test during treatment with Dextran Sulphate Sodium (DSS)-induced mice colitis. Weight loss, colonic histology were measured. Furthermore, the gut microbiome of mice before and post colitis treatments were performed by 16S rRNA-ba...